Home: NFLIS

Over 1.1 million drug reports in 2025

Established in 1997, the National Forensic Laboratory Information System (NFLIS) is a program of the Drug Enforcement Administration (DEA). The DEA's NFLIS-Drug data collection systematically collects drug identification results and associated information from drug cases submitted to and analyzed by participating U.S. federal, state, and local forensic laboratories with drug chemistry sections. In 2025, a total of 1,126,178 drug reports were submitted to NFLIS.

Join NFLIS

Laboratory workers looking at NFLIS website on a laptop

NFLIS actively invites new laboratories to join our growing program. Participating laboratories benefit from access to a comprehensive forensic database, keeping them updated on emerging trends and newly identified substances in near real-time. By reporting data to NFLIS, laboratories enhance the accuracy of our national understanding of drug use and trafficking patterns, thereby aiding policymakers in making informed decisions. By sharing data and insights, participants help create a more unified and effective response to the drug challenges facing our communities. Moreover, NFLIS participation supports the development of best practices and contributes to continuous improvements in forensic science methodologies. We encourage laboratories to consider participating in NFLIS by emailing their interest to: NFLIS@dea.gov.

DEA Diversion Website Synth-Opioid Network Data Query System Overview NFLIS Substances

NFLIS News

DOSE: 5-Chloro Desmethyl Chlorphine (May 2026)

An unknown material was submitted to the DEA Special Testing and Research Laboratory through the DEA Overdose Surveillance Exchange (DOSE) program. The sample was a white powder suspected to contain fentanyl which was seized by the Knoxville (TN) Police Department and transferred to DEA in May 2026. It was found to contain 5-chloro desmethyl chlorphine with an estimated 34% purity. Get the Public Alert.
DOSE: JWH-018-S (March 2026)

Substance was submitted by the DEA Western Laboratory as an unknown substance. A total of eleven bottles containing liquid were obtained in the State of Washington in April 2025. One of the bottles contained MDMB-4en-PINACA, CH-PIATA, and ADB-FUBIATA. The remaining ten bottles contained the unknown substance. Get the Public Alert.
DOSE: sec-Butyl Butylone (March 2026)

Substance was submitted by the DEA Southeast Laboratory as an unknown substance. The sample was a white powder seized by DEA in Florida in November 2025 and suspected to contain fentanyl. This is the first time sec-Butyl Butylone has been identified by DEA or reported in the United States. Get the Public Alert.
NFLIS-Drug Snapshot (March 2025)

Six new substances that were reported from across the U.S. between January 1, 2025, and March 31, 2025, are highlighted in this Snapshot. Top drugs in selected categories and recent trends for carfentanil, MDMA, and medetomidine are also reported. Get the Snapshot.
NFLIS-Drug Snapshot (December 2024)
Six new substances that were reported from across the U.S. between October 1, 2024, and December 31, 2024, are highlighted in this Snapshot. Top drugs in selected categories and recent trends for ketamine, cocaine, and fentanyl are also reported. Get the Snapshot.
NFLIS-Drug Bulletin (September 2024)

Eighteen new substances that were reported from across the U.S. between January 1, 2024, and September 30, 2024, are highlighted in this special Bulletin. Get the Bulletin.