Session Idle Alert

You will be logged out in due to inactivity. Please click Ok to extend the session or select Log Out to end the session.

NFLIS-Drug Forensic Laboratories with Drug Chemistry Sections

Drug Cases Submitted to Participating Federal, State, and Local Laboratories

Cases with a submission date between January 1, 2025 and December 31, 2025

Number of cases submitted to labs in 2025 666,357
Number of reports (substance identifications) associated with the cases above. 1,126,178

The most frequently identified substances in selected categories (percentage of all reports):

Category Substance Percentage
Drug Methamphetamine
28.72%
Narcotic Analgesic Fentanyl
11.74%
Tranquilizer/Depressant Xylazine
1.61%
Synthetic Cannabinoid MDMB-4en-PINACA
0.42%

New Substances Reported in 2025

  • 1-Benzoylpiperazine
  • 1-Boc-4-hydroxypiperidine
  • 2,2,6,6-Tetramethyl-4-piperidinol
  • 2,2,6,6-Tetramethyl-N-phenylpiperidin-4-amine (TM-4-AP)
  • 2,5-Dimethoxy-beta-nitrostyrene
  • 2-bromo-4'-chloropropiophenone
  • 2-Methyl-3-phenyloxirane-2-carboxylic acid (BMK Glycidic Acid)
  • 2-Methyl-alpha-PiHP
  • 3,4,5-Trimethoxy-beta-nitrostyrene
  • 4-Propanoyloxy DMT
  • 7-Hydroxymitragynine
  • 9(R)-Hexahydrocannabiphorol
  • AB-MDMSBA
  • alpha-Pyrrolidinoisoheptanophenone (iso-PV8; alpha-PiHPP)
  • Cinazepam
  • CUMYL-PINACA
  • Daridorexant
  • Decahydronaphthalene
  • Deflazacort
  • delta-4(8)-Isotetrahydrocannabinol (delta-4(8)-iso-THC)
  • delta-8-Tetrahydrocannabivarin (delta-8-THCV)
  • Ethylbromazolam
  • fluoro-alpha-PPP, isomer undetermined
  • Lauric acid (dodecanoic acid)
  • Lemborexant
  • MDMB-MINACA
  • meta-Fluorobutyryl fentanyl (m-Fluorobutyryl Fentanyl; m-FBF)
  • meta-Methylfentanyl (m-Methyl Fentanyl)
  • Methyl N-Boc-4-oxopiperidine-3-carboxylate
  • Methyl-alpha-PiHP, isomer undetermined
  • Mitragynine pseudoindoxyl
  • N,N-Dimethylamino Etonitazene
  • Naldemedine (Symproic)
  • N-benzyl-N-(1-phenethylpiperidin-4-yl)propionamide (Fentanyl methylene homolog)
  • N-cyclohexyl Pentylone
  • Nifoxipam
  • Nilotinib
  • N-isobutyl Methylone (3,4-Methylenedioxy-N-isobutyl cathinone)
  • N-isopropyl-N-methyl Methylone
  • N-Methyl hexylone
  • N-Phenethyl Tetramethyl-4-AP (PE-TM-4-AP)
  • N-Phenethylmorpholine (4-(2-phenylethyl) Morpholine)
  • N-Phenethyl-N-phenylpropionamide
  • N-propionyl para-fluoro Norfentanyl
  • N-Pyrrolidino Isotonitazene
  • ortho-Methylfentanyl (o-Methyl Fentanyl)
  • para-fluoro Norfentanyl
  • Protodesnitazene
  • Rilmazolam
  • Savaysa (Edoxaban)
  • Spirochlorphine (R-6890)
  • SR 17018 (5,6-Dichloro Desmethylchlorphine)
  • W-19 (N-[1-[2-(4-aminophenyl)ethyl]-2-piperidinylidene]-4-chloro-benzenesulfonamide)

Top 25 Most Frequently Identified Drugs in 2025

Rank Drug Number of Reports
1Methamphetamine 323,404
2Cocaine 195,317
3Cannabis 143,689
4Fentanyl 132,210
5Heroin 27,286
6Xylazine18,138
7Oxycodone 12,792
8Alprazolam 12,373
9Buprenorphine11,225
10Medetomidine8,980
11BTMPS8,138
124-ANPP (Fentanyl precursor)8,031
13Amphetamine7,496
14Psilocin7,370
15MDMA 7,161
16Fluorofentanyl6,708
para-Fluorofentanyl3,535
Fluorofentanyl (unspecified isomer) 3,157
ortho-Fluorofentanyl 14
meta-Fluorofentanyl 2
17Ketamine 6,567
18Dimethylsulfone 6,051
19delta-8-Tetrahydrocannabinol 5,665
20Hydrocodone 4,875
21MDMB-4en-PINACA 4,726
22Tramadol 4,336
23Clonazepam 4,155
24Gabapentin 2,949
25Naloxone 2,827