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NFLIS-Drug

Over 1.1 million drug items reported in 2024

Established in 1997, the National Forensic Laboratory Information System (NFLIS) is a program of the Drug Enforcement Administration (DEA). The DEA's NFLIS-Drug data collection systematically collects drug identification results and associated information from drug cases submitted to and analyzed by participating Federal, State, and local forensic laboratories with drug chemistry sections. In 2024, a total of 1,111,895 drug items were reported by State and local forensic laboratories in the United States.
NFLIS-TOX

About 28 million toxicology requests were referred to responding toxicology laboratories in 2019

Toxicology laboratories are a vital source for identifying drugs used by the public. Data from toxicology laboratories can serve as an early warning system to alert the public health community and law enforcement of the drugs they may encounter, leading to improved treatment, prevention, and enforcement policies. The addition of toxicology data to NFLIS is vital for helping DEA improve drug scheduling, enhance available drug intelligence, and better engage their public health partners.
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NFLIS-MEC

700,000 death cases were accepted by medical examiner and coroner offices (MECs) in 2021, with over 100,000 of those being overdose cases.

MECs are an important data resource for identifying drugs that are used by the public and are potentially deadly. NFLIS-MEC will help DEA improve drug scheduling, enhance available drug intelligence, and better engage DEA’s public safety and public health partners.
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NOTICE: NFLIS may experience intermittent outages due to maintenance from April 10 to April 14. Service should resume by April 15. We apologize for any inconvenience. If you have any questions, please reach out to us at NFLIS@dea.gov.

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Forensic Laboratories

Toxicology Laboratories

Medical Examiners and Coroners Offices

DEA Diversion Website Synth-Opioid Network Data Query System Overview NFLIS Substances

NFLIS News

DOSE: JWH-018-S (March 2026)

Substance was submitted by the DEA Western Laboratory as an unknown substance. A total of eleven bottles containing liquid were obtained in the State of Washington in April 2025. One of the bottles contained MDMB-4en-PINACA, CH-PIATA, and ADB-FUBIATA. The remaining ten bottles contained the unknown substance. Get the Public Alert.
DOSE: sec-Butyl Butylone (March 2026)

Substance was submitted by the DEA Southeast Laboratory as an unknown substance. The sample was a white powder seized by DEA in Florida in November 2025 and suspected to contain fentanyl. This is the first time sec-Butyl Butylone has been identified by DEA or reported in the United States. Get the Public Alert.
NFLIS-Drug Snapshot (March 2025)

Six new substances that were reported from across the U.S. between January 1, 2025, and March 31, 2025, are highlighted in this Snapshot. Top drugs in selected categories and recent trends for carfentanil, MDMA, and medetomidine are also reported. Get the Snapshot.
NFLIS-Drug Snapshot (December 2024)
Six new substances that were reported from across the U.S. between October 1, 2024, and December 31, 2024, are highlighted in this Snapshot. Top drugs in selected categories and recent trends for ketamine, cocaine, and fentanyl are also reported. Get the Snapshot.
NFLIS-Drug Bulletin (September 2024)

Eighteen new substances that were reported from across the U.S. between January 1, 2024, and September 30, 2024, are highlighted in this special Bulletin. Get the Bulletin.